Regulation of 18-Hydroxydeoxycorticosterone in the Rat
- 1 April 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 102 (4) , 1113-1117
- https://doi.org/10.1210/endo-102-4-1113
Abstract
Simultaneous measurements of plasma 18-hydroxydeoxycorticosterone (18-OH-DOC), corticosterone and aldosterone were performed in the rat by using RIA [radioimmunoassay]. Under basal conditions, 18 OH-DOC levels averaged 11.3 .+-. 3.7 (SE) ng/ml. Plasma concentrations were increased 8-fold (86.8 .+-. 8.0 ng/ml) 1 h after 1 U [unit] s.c. ACTH. Dexamethasone suppressed 18 OH-DOC to less than 1.5 ng/ml, irrespective of Na+ intake. Neither Na+ depletion nor Na+ loading had any influence on 18 OH-DOC levels. Excellent correlation between 18 OH-DOC and corticosterone (r = 0.90, P < 0.001) was observed, whereas there was none between 18 OH-DOC and aldosterone (r = 0.061, P > 0.6). In the rat, 18 OH-DOC is an ACTH-dependent steroid which does not appear to be under the influence of the renin-angiotensin system.This publication has 3 references indexed in Scilit:
- Radioimmunoassay of 18-hydroxy-ll-deoxycorticosterone in PlasmaJournal of Clinical Endocrinology & Metabolism, 1976
- The regulation of plasma 18-hydroxy 11-deoxycorticosterone in man.Journal of Clinical Investigation, 1976
- Secretion of 18-Hydroxydeoxycorticosterone by the Rat Adrenal GlandEndocrinology, 1963