Intergenomic consensus in multifactorial inheritance loci: the case of multiple sclerosis
Open Access
- 1 December 2004
- journal article
- research article
- Published by Springer Nature in Genes & Immunity
- Vol. 5 (8) , 615-620
- https://doi.org/10.1038/sj.gene.6364134
Abstract
Genetic linkage and association studies define chromosomal regions, quantitative trait loci (QTLs), which influence the phenotype of polygenic diseases. Here, we describe a global approach to determine intergenomic consensus of those regions in order to fine map QTLs and select particularly promising candidate genes for disease susceptibility or other polygenic traits. Exemplarily, human multiple sclerosis (MS) susceptibility regions were compared for sequence similarity with mouse and rat QTLs in its animal model experimental allergic encephalomyelitis (EAE). The number of intergenomic MS/EAE consensus genes (295) is significantly higher than expected if the animal model was unrelated to the human disease. Hence, this approach contributes to the empirical evaluation of animal models for their applicability to the study of human diseases.Keywords
This publication has 45 references indexed in Scilit:
- Non-linear conversion between genetic and physical chromosomal distancesBioinformatics, 2004
- Involvement of the Ubiquitin-Proteasome System in the Early Stages of Wallerian DegenerationNeuron, 2003
- Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowthNature, 2002
- Mapping and analysis of quantitative trait loci in experimental populationsNature Reviews Genetics, 2002
- The range of multiple sclerosis associated with neurofibromatosis type 1Journal of Neurology, Neurosurgery & Psychiatry, 2001
- Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2Science, 1999
- Monte Carlo SimulationTechnometrics, 1998
- Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.Journal of Clinical Investigation, 1998
- Human Postsynaptic Density-95 (PSD95): Location of the Gene (DLG4) and Possible Function in Nonneural as Well as in Neural TissuesGenomics, 1997
- TAP2 gene polymorphism contributes to genetic susceptibility to multiple sclerosisHuman Immunology, 1995