SPLANCHNIC PRODUCTION AND UPTAKE OF ENDOGENOUS TRIGLYCERIDES IN THE FASTING STATE IN MAN*

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Abstract
The net splanchnic production of triglycerides and of radioactive triglycerides after the injection of albumin-bound palmitate-1-C14 was studied simultaneously in the fasting state in man by liver vein catheterization. No net production of triglycerides could be demonstrated over the splanchnic region. Up to 70 minutes after the injection of labeled palmitic acid there was a significant splanchnic net production of radioactive triglycerides. The estimated splanchnic net production of radioactive triglycerides compared well with the calculated amount of radioactive triglycerides present in the plasma compartment. The data have been taken as an indication that, considering methodological errors, the net transport of triglycerides to the periphery was less than [plus or minus] 2 moles/hour. Furthermore, the data indicate that there is a rapid exchange of triglyceride fatty acids between the liver and plasma triglyceride pools. This process was much more rapid than any net transfer of triglycerides from these pools to the periphery.