UNESTERIFIED FATTY ACID IN HUMAN BLOOD PLASMA 1

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Abstract
Concentration of unesterified fatty acid (UFA) was measured in human blood plasma by the method of Davis. Values in normal individuals rise after ingestion of fat, but rise similarly on fasting, so that lipemia per se cannot be shown to produce a rise in UFA. Glucose feeding produces a uniform fall, whereas epinephrine injection causes an increase. The hypothesis is offered that UFA is the blood lipid fraction primarily concerned with the supply of fats to tissues for oxidative catabolism. The extraction of this substance by tissues was shown and evidence suggesting its origin in adipose tissue obtained.