Preference thresholds for quinine hydrochloride in chimpanzee, monkey and rat.

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Abstract
The preference method involved presenting the animals (1 chimpanzee, Pan satyrus; 15 monkeys, Macaca mulatta; and 9 albino rats) with 6 containers (8 for the chimpanzee), half of which contained tap water and half of which contained a soln. of quinine hydrochloride. All fluid intake during the exptl. period was from these containers. 2 exptl. periods were run for each conc. of quinine. For each animal the quinine soln. intake (expressed as a % of total fluid intake for the 2 exptl. periods) was plotted against quinine conc. Quinine was presented temporally in high concs. first, and in descending conc. in an approx. geometric series (ratio = 0.5) from 0.2 gm./100 ml. to 0.0003 gm./100 ml. for monkeys and chimpanzees and from 0.1 gm./lOO ml. to 0.000025 gm./lOO ml. for rats. From these curves, acceptance thresholds (the highest conc. at which animal consumed quinine as readily as tap water) and rejection thresholds (the conc. at which quinine was consumed only to the extent necessary to determine which of the containers contained the quinine) were detd. Modal acceptance thresholds were: for monkey, 0.025 gm./lOO ml.; for chimpanzee, 0.0062 gm./100 ml.; for the rat, 0.0003 gm./lOO ml. These are compared with the approx. comparable value for man (from other studies) of 0.0025 gm./100 ml.

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