Maternal-Fetal Mortality in Mice with Isoantibodies to Paternal y-Globulin Allotypes

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Abstract
Summary A high incidence of maternal and fetal deaths has been observed in pregnant mice with isoantibodies to paternal y-globulin allotypes. BALB/c females were immunized to produce isoantibodies to C57BL/6 y-globulin and mated to C57BL/6 males; similarly, C57BL/6 females were immunized to produce isoantibodies to BALB/c y-globulin and mated to BALB/c males. Fifty per cent of the BALB/c pregnant mice succumbed at term; the number of progeny surviving per pregnant mouse was 30% of the control groups. No maternal deaths occurred in the C57BL/6 pregnant mice; no live progeny were delivered. Retention of fetuses in utero as well as grossly misshapen and severely bruised fetuses were observed in both strains.

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