HLA class II genes poIymorphism in DR4 giant cell arteritis patients
- 1 November 1988
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 32 (5) , 254-258
- https://doi.org/10.1111/j.1399-0039.1988.tb01664.x
Abstract
We have previously reported a significant increase of HLA-DR4 antigen frequency in giant cell arteritis (GCA). This finding suggested an important role of immunogenetic factors in this syndrome. Recent data suggest that inherited susceptibility to several autoimmune diseases was associated with specific DR4 associated DQ .beta. alleles. DNAs from 27 DR4 postive patients with GCA were digested with Taq I and Bam HI, analysed on 0.7% agarose gel and hybridized with DR .beta.. DQ .alpha. and DQ .beta. probes. DR .beta. hybridization produced no variant detectable within DR4. DQ .beta. probe confirmed two clusters among DR4 associated DQW3 alleles: DQW 3.1 (Bam HI 360 Kb) and DQw 3.2 (Taq I 1.9 Kb and Bam HI 11 Kb). Among our 27 DR4 postive patients, 34% were DQW 3.1 and 66% were DQW 3.2. These frequencies are the same as those observed in healthy controls.This publication has 15 references indexed in Scilit:
- HLA-DQ BETA-CHAIN POLYMORPHISM IN HLA-DR4 HAPLOTYPES ASSOCIATED WITH RHEUMATOID ARTHRITISThe Lancet, 1987
- HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitusNature, 1987
- Structure and expression of HLA-DQ ? and -DX ? genes: interallelic alternate splicing of the HLA-DQ ? gene and functional splicing of the HLA-DX ? gene using a retroviral vectorImmunogenetics, 1987
- Molecular characterization of three HLA class II molecules on DR4 and DRw9 haplotypes: Serologic and structural relationships at the polypeptides levelHuman Immunology, 1986
- Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.Proceedings of the National Academy of Sciences, 1985
- DR5-Associated DC molecules carry three different allospecificitiesHuman Immunology, 1985
- HLA DR4 and giant cell arteritisTissue Antigens, 1984
- Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity and HLA-D.Proceedings of the National Academy of Sciences, 1983
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- Increased Prevalence of HLA-DR4 in Giant-Cell ArteritisNew England Journal of Medicine, 1981