Anion inhibitor-sensitive unidirectional sodium movements in the human erythrocyte.
Open Access
- 1 July 1978
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 72 (1) , 87-100
- https://doi.org/10.1085/jgp.72.1.87
Abstract
The increased unidirectional sodium influx found when human erythrocytes are suspended in isotonic salt solutions containing bicarbonate ions as a replacement for chloride ions was examined. The increased sodium movement appears to have the transport characteristics of anion movement. Inhibitors of anion transport such as furosemide, fluorodinitrobenzene (FDNB), and 4-acetamido-4'-isothiocyano-stilbene-2-2'-disulfonic acid (SITS) drastically inhibit these augmented sodium movements. An ion-pair mechanism appears to phenomenologically describe much of the data. A possible role for carbamino groups is considered. Such a model, however, required additional assumptions to explain the selectivity and the anion inhibitor effects.This publication has 3 references indexed in Scilit:
- Furosemide inhibition of chloride transport in human red blood cells.The Journal of general physiology, 1976
- Effects of Some Monovalent Anions on Fluxes of Na and K, and on Glucose Metabolism of Ouabain Treated Human Red CellsActa Physiologica Scandinavica, 1967
- Automatic pH Regulation of Cell Suspensions by a Gasometric pH-StatScandinavian Journal of Clinical and Laboratory Investigation, 1962