Hypercalcemic Infantile Renal Tumors: Morphological, Clinical, and Biological Heterogeneity

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Abstract
Hypercalcemic infantile renal tumors without bone metastases should be considered to be a heterogeneous tumoral enti. Histological and ultrastructural features, different from those of nephroblastoma, should not be exclusively linked with malignant rhabdoid tumors of the kidny. This is reported by the present case, which appears to be a cellular variant of mesoblastic nephroma and was successfully serially transplanted to nude mice. The causes of hypercalcemia in infantile renal tumors are probably related either to NH,-teminal parathonone or to prostaglandin E2 production by the tumoral cells.