Nuclear analogs of β-lactam antibiotics. X. Synthesis of 2-substituted desthiocephalosporins
- 15 January 1979
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 57 (2) , 222-226
- https://doi.org/10.1139/v79-036
Abstract
The syntheses of the desthiocephem system from the enol 2 is described. Thus conversion of 2 to its triflate 3 followed by treatment with the sodium salts of malonate esters gave the cyclized products 4a–c. Azide reduction followed by coupling of phenoxyacetic acid and hydrogenolysis gave the acids 7 and 8. Compound 15 was also prepared.This publication has 4 references indexed in Scilit:
- Nuclear analogs of β -lactam antibiotics. IX. Synthesis of 7-methoxy 2-isocephems and O-2 isocephemsCanadian Journal of Chemistry, 1978
- Nuclear analogs of β-lactam antibiotics. VIII. Synthesis of 3-acetoxymethyl-Δ3-O-2-isocephemsCanadian Journal of Chemistry, 1978
- Nuclear analogs of β-lactam antibiotics. VII. Synthesis of 2-isocephemsCanadian Journal of Chemistry, 1977
- Nuclear analogs of β-lactam antibiotics. VI. Synthesis of N-2-isocephemsCanadian Journal of Chemistry, 1977