Effect of Isoniazid on Vitamin B6 Metabolism; Its Possible Significance in Producing Isoniazid Neuritis.
- 1 March 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 85 (3) , 389-392
- https://doi.org/10.3181/00379727-85-20891
Abstract
The excretion of an excess of vit. B6 was demonstrated in patients receiving isoniazid (INH), with the irregular appearance of abnormal amts. of xanthurenic acid following a test dose of tryptophane. The effect is more marked in those getting a higher dose of INH. Such laboratory evidence of B6 abnormality provides a cause of peripheral neuritis. Preliminary results suggest that the addition of pyridoxine to a high dose of INH prevents neuritis, which otherwise occurs in 40% of the cases.Keywords
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