Thiosemicarbazide Toxicity in Mice.

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Abstract
Fatal convulsions follow the admn. of thiosemicarbazide to mice. Semicarbazide is only 5% as toxic as thiosemicarbazide while aminoguanidine is non-toxic. The toxicity of thiosemicarbazide is completely reversed by stoichiometric doses of pyridoxamine but very poorly reversed by pyridoxine or pyridoxal. Dietary restriction of B6 did not influence its toxicity. Pyruvic acid, alpha-ketoglutaric acid, gamma- aminobutyric acid, glutamic acid and CaCl2 did not reverse the toxicity, nor enhance sub-optimal doses of pyridoxamine.

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