Reduced tubular reabsorption of phosphate during post-operative glucose infusions in humans

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Abstract
Serum phosphate concentration decreases considerably during postoperative glucose infusions. Whether the renal handling of phosphate is responsible for this fall was determined. Patients (12) were studied during glucose and saline infusions on the 2 first post-operative days. The maximal tubular capacity for reabsorption of phosphate per l of glomerulus filtrate (TmP/GFR) was significantly reduced during glucose infusions in relation to saline infusions. The glucose induced fall in serum phosphate concentration was correlated to the change in TmP/GFR (r2 = 0.71). The reduced TmP/GFR during the glucose infusions was not explained, but a high correlation was found between TmP/GRF and the changes in plasma glucose concentration during the infusions (r = -0.91).