A MYOTROPHIC AGENT AND GONADOTROPHIN INHIBITOR, 19-NORTESTOSTERONE-17-BENZOATE

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Abstract
19-Nortestosterone-17-benzoate, a new ester of 19-nortestosterone, has been compared with testosterone propionate for several biological activities. Testosterone propionate and 19-nortestosterone-17-benzoate are myotrophic and suppress production or release of pituitary gonadotrophins. Unlike testosterone propionate, the 19-nortestosterone derivative elicits these responses in doses which do not stimulate growth of seminal vesicles and ventral prostate in rats. The uterotrophic, anti-estrogenic and progestational potencies of the 2 androgens are similar. 19-Nortesto-sterone-17-benzoate is devoid of estrogenic activity. A 6-week study in intact and castrate male and female rats demonstrated that the biologic properties of 19-nortestosterone-17-benzoate are typical of those of an androgen. This steroid was orally inactive at the dose tested.