THE FATE OF BRANCHED CHAIN FATTY ACIDS IN ANIMAL BODY. II. CHEMICAL CHANGES OF SOME SYNTHETIC BRANCHED-CHAIN FATTY ACIDS IN VIVO*

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Abstract
Rabbits were injd. subcut. with the following branched-chain aliphatic compounds: 3-methylpelargonic acid, 2-methylcaprylic acid, 3-ethylenantic acid, 2-ethylhexanol, 2-butylcaproic acid, 3-propylcaproic acid. In each instance 10-30% of the injd. material was recovered from the urine as dicarboxylic acid, indicating that [omega] -oxidation of the fatty acid chain had taken place. Obviously side chains favor [omega] -oxidation, as demonstrated by the urinary excretion of dibasic acids, since after admn. of straight aliphatic chains urinary excretion of dibasic acids never exceeds 5.8% of the ingested compound.

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