Cloning of a human cDNA expressing a high voltage‐activating. Tea‐sensitive, type‐a K+ channel which maps to chromosome 1 band p21

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Abstract
Over ten different mammalian genes related to the Drosophila Shaker gene (the Sh gene family) have been identified recently. These genes encode subunits of voltage‐dependent K+ channels. The family consists of four subfamilies: ShI genes are homologues of Shaker; ShII, ShIII, and ShIV are homologues of three other Shaker‐like genes in Drosophila, Shab, Shaw, and Shal, respectively We report here the cloning of a human K+ channel cDNA (HKShIIIC) obtained from a brain stem cDNA library. HKShIIIC transcripts express an atypical voltage‐dependent transient (A‐type) K+ current in Xenopus oocytes. This current is activated by large membrane depolarizations and is extremely sensitive to the K+ channel blocker TEA unlike most A‐type currents. The gene encoding HKShIIIC maps to chromosome 1p21.