A Dose-Response Study of Xipamid in Hypertension Used in Combination with other Anti-Hypertensive Drugs

1 November 1975

journal article
Published by SAGE Publications in Journal of International Medical Research

Vol. 3 (6) , 389-394
https://doi.org/10.1177/030006057500300606

Abstract

Xipamid has been found to exert an effective anti-hypertensive effect in combination with methyldopa ( four patients), propranolol ( five patients), methyldopa and propranolol ( one patient) and bethanidine ( one patient), also bethanidine and propranolol ( two patients). A double-blind study was performed in ten patients and xipamid 40 mg and 20 mg produced a significant fall in blood pressure, but the difference in effect between the two dosages was insignificant. Xipamid produced a fall in serum potassium below the normal range in half the patients. Xipamid is an effective anti-hypertensive drug that exerts an additive effect with other anti-hypertensive drugs in common with many other diuretic agents.

Keywords

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