1,25 dihydroxyvitamin D3increases plasma magnesium and calcium in sheep fed liquid diets low in calcium and magnesium

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Abstract
Sheep given a liquid diet low in Ca and Mg by infusion directly into the abomasum developed concurrent hypocalcemia and hypomagnesemia, with plasma concentrations of Ca and Mg decreasing to 2.0 and 0.4 mmol/l, respectively. Treatment of these hypomagnesemic sheep with 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) increased the plasma Ca, Mg and P concentrations with plasma Ca increasing to 2.5 mmol/l and plasma Mg to 0.6 mmol/l. Plasma Mg increased despite a small but significant increase in the daily excretion of Mg in the urine, and the amount of Mg derived from either bone and/or intestine must have been greater than the amount lost in the urine. Since in other experiments it was demonstrated that plasma Ca remains within the normal range when a liquid diet adequate in Mg but low in Ca is infused, these results imply that either synthesis of and/or end organ response to 1,25(OH)2D3 is impaired in Mg deficient sheep.