Metabolism of Propionate-1-C-14 in the Intact Mouse.

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Abstract
Twenty-four normal and 16 obese mice were injected with radioactive propionate to determine if this compound was selectively incorporated into long-chain lipids by the fat depots of the intact mouse. Propionate is a precursor for body fat synthesis. The fatty acid uptake curve for obese mice reached a maximum value 4 times greater than the curve for normal mice. The peak of the obese curve occurred at 5 hr. after injection while the peak for the normal curve was reached at 17 hr. The results show that injected propionate is incorporated into lipids to a greater extent by fat animals. They indicate the rapid turnover that body fat may have.