A Comparison of Effect of Caronamide and Benzoic Acid on Penicillin Plasma Concentrations

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Abstract
Inhibition of the renal tubular excretion of penicillin elevates the plasma conc. of penicillin. This inhibition can be accomplished physiologically and reversibly by parenteral adm. of large amts. of diodrast or [rho]-aminohippuric acid, or by oral adm. of caronamide. Although it has been claimed that benzoic acid and Na benzoate adm. orally inhibit the excretion of penicillin, the necessity of restricting fluid and salt intake to obtain the best results limits the application of this method in practice. There are few reports on the use of benzoic acid and no comparisons with caronamide. Benzoic acid and caronamide were adm. orally to the same patients, with unrestricted food and liquid intake, on separate days in doses of 16 and 24 g./day. Each patient was studied with the aid of penicillin dose response curves in a control period and in benzoic acid and caronamide-treatment periods. In some cases benzoic acid was given prior to caronamide and in other cases vice versa. Benzoic acid failed to show any enhancing effect whereas caronamide showed on the av. 5-fold increases of penicillin plasma conc. over control values.