Intravenous Amodiaquin (Camoquin 1) in Naturally Acquired and Induced Malaria

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Abstract
Amodiaquin (Camoquin Hydrochloride), a synthetic antimalarial, has been studied by different investigators, (1, 2, 3, 4, 5, 6, 7) and its high effectiveness by oral administration against the different species of pathogenic plasmodia has been proved. All of them confirm the rapidity with which the parasites disappear from the circulating blood and the resulting remission of the acute symptoms of the disease. This drug is the dihydrochloride dihydrate of 4-(3′-diethyl-aminomethyl-4′-hydroxyanilino)-7-chloroquinoline and is soluble in water in a concentration of 5% at room temperature resulting in a clear yellow solution. Oral administration when possible, is preferable to other forms of administration in all antimalarial treatment. However, it is necessary to remember that an effective and dependable antimalarial for parenteral administration having rapid action is a valuable weapon for the treatment of the algid state, comatose patients, those who are vomiting or who have diarrhea which prevents good absorption of the medication from the intestine.

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