Atropine serum concentrations after multiple inhaled doses of atropine sulfate

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Abstract
Atropine may be given by inhalation for bronchodilation. I.v. atropine at doses of 0.32-1 mg yields serum levels of 2-6 ng/ml, with an elimination t1/2 [half-time] of about 4 h. Efficient inhalation of large single doses leads to similar concentrations in some individuals, but under clinical conditions drug delivery may be less efficient. Of concern is accumulation of the drug in the body with multiple-dose therapy. Serum levels of atropine were measured after single inhaled doses and again after 48-72 h of inhalation every 4-6 h in 11 subjects. The drug was administered by therapists at doses and techniques commonly used in the clinical setting. Serum concentrations of atropine were negligible after the 1st dose in all subjects but were detectable in 6 of 9 subjects who received the drug for more than 48 h. Three of the subjects had levels > 2 ng/ml.

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