Estimating the glomerular filtration rate

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Abstract
Early detection and management of chronic kidney disease (CKD) hold the promise of decreasing the risk of complications of CKD and preventing kidney failure. One of the challenges, however, is that the early stages of CKD are silent and are detectable only through laboratory analyses. Glomerular filtration rate (GFR) remains the most accurate index of kidney function—and is thus key to early management of the disease. In this article, Drs Manjunath, Sarnak, and Levey offer information on how best to estimate GFR and outline limitations of using prediction equations.