Assessment of Conventional Criteria for the Early Diagnosis of Thrombophlebitis with the125l-Fibrinogen Uptake Test

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Abstract
Analysis of 55 positive tests of a total of 300 tests by conventional criteria revealed that 125I-fibrinogen provides useful information early enough for clinical management in humans. Of the tests which were ultimately interpreted as positive by conventional criteria, at least 1 was positive at 3-4 h in 67% of the tests and 98% of the tests were positive at 24 h after the administration of 125I-fibrinogen. A 20% difference between contralateral identical locations of the legs and a 20% difference between adjacent locations of the ipsilateral leg were found with almost equal frequency in the positive tests; a 20% increase at the same location was less sensitive. The 125I-fibrinogen uptake test is a simple and accurate technique for the early diagnosis of active thrombophlebitis.

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