Benzo[a]pyrene Content and Carcinogenicity of Cigarette Smoke Condensate—Results of Short-Term and Long-Term Tests2

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Abstract
We report the results of 2 investigations which may contradict the idea that benzo[a]pyrene (BP) plays a leading part in carcinogenesis of mouse skin by cigarette smoke condensate. A study of several natural condensates showed no correlation between their BP content and activity in short-term tests, i.e., activity in sebaceous-gland and hyperplasia tests; when the BP content of a condensate was increased up to 30 times the initial amount, the results showed no increase of activity, either in short-term or in long-term tests (carcinogenesis). Thus we may conclude that BP content is not important in the carcinogenicity of cigarette smoke condensate.