Studies on antibiotics
- 1 January 1947
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 41 (3) , 463-469
- https://doi.org/10.1042/bj0410463
Abstract
Geodin was isolated from the culture medium of Aspergillus terreus N.C.T.C. 3911. It possesses high antibiotic activity against Gram-positive bacteria. Various substances chemically related to penicillic acid and clavatin were synthesized and tested. Antibacterial activity is associated with the following structure C[long dash]CO[long dash]C=C[long dash]with an H atom on the a or [beta][long dash]C atom. The inhibitory effect of cys-teine on these antibiotics indicates that the antibiotic activity involves an enzyme system containing[long dash]SH groups.This publication has 7 references indexed in Scilit:
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- The Synthesis of a Clavacin Isomer and Related Compounds1Journal of the American Chemical Society, 1945
- The Synthesis of a Clavacin IsomerScience, 1945
- An Antibacterial Substance from Aspergillus clavatus and Penicillium claviforme and its Probable Identity with PatulinNature, 1943
- Studies in the biochemistry of micro-organismsBiochemical Journal, 1936
- Studies in the biochemistry of micro-organismsBiochemical Journal, 1936
- Studies in the biochemistry of micro-organismsBiochemical Journal, 1935