THE EFFECT OF SOME ANABOLIC STEROIDS ON THE EXCRETION OF URINARY GONADOTROPHINS

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Abstract
SUMMARY: 1. The mouse uterus test has been used to determine the urinary excretion of total gonadotrophin. Patients likely to have a consistently high excretion of gonadotrophins were used for study. 2. One patient was treated with 17α-methyl androstane-3α: 17β-diol, and urinary gonadotrophin was unchanged. 3. 17α-Methyl-androst-5-ene-3β: 17β-diol and 17α-ethyl-19-nortestosterone in doses used therapeutically to produce nitrogen retention do not depress urinary gonadotrophin, although in sufficiently high dosage they may possibly do so. 4. In one of two patients treated with testosterone propionate the excretion of urinary gonadotrophin was depressed.