Experience with a Quantitative Test for Normal or Decreased Amounts of Follicle Stimulating Hormone in the Urine in Endocrinological Diagnosis

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Abstract
Use of the method of Heller and Heller with slight modifications revealed the following excretion levels of F.S.H.:[long dash]35 normal individuals, ages 20-45, more than 6.6 M.U:/24 hrs.; 10 patients with acromegaly[long dash]2 with normal excretion levels, 7 with decreased levels (attributed to destruction of basophil cells), and 1 with an increased excretion level (post-menopausal); 14 patients with panhypopituitarism, levels below 6.6 M.U./24 hrs.; 2 cases of primary amenor-rhea, decreased excretion; and 9 cases with clinical evidence of virtual lack of estrin production. In tests for excretion levels of F.S.H. it appears possible to divide cases of hypoestrinism into 3 categories: (a) ovarian hypoestrinism, a primary ovarian deficiency associated with increased excretion of F.S.H.; (b) pituitary hypoestrinism due to primary lack of production of F.S.H.; (c) hypothalamic hypoestrinism due to disturbance in the hypothalamo-pituitary nervous pathway and associated with a normal excretion level of F.S.H.