GONADOTROPINS OF THE SWINE PITUITARY I. VARIOUS BIOLOGICAL EFFECTS OF PURIFIED THYLAKENTRIN (FSH) AND PURE METAKENTRIN (ICSH)

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Abstract
Metakentrin (ICSH) isolated from swine pituitary glands stimulated the testicular interstitial cells of hypophysectomized male rats to secrete androgen. Adrenal cortical extract and desoxycorticosterone acetate caused no enlargement of the prostate. Metakentrin also produced an hypertrophy of the interstitial cells in immature [male] pigeons. In hypophysectomized [female] rats this hormone brought about maintenance or repair of the interstitial cells; the persisting corpora lutea were not destroyed or rendered functional by metakentrin. Metakentrin antagonized the gonadotropic action of pregnant mare serum. Metakentrin prepared from swine and from sheep showed no qualitative species difference although certain quantitative differences were noted. Thylakentrin (80% pure FSH) had a specific action on the seminiferous tubules and caused no androgen production. In hypophysectomized [female] rats it caused follicular growth with no estrogen production but when thylakentrin was combined with metakentrin estrogen was secreted and corpora lutea appeared. Metakentrin and thylakentrin were about equally effective in causing ovulation of estrous does.