Therapeutic Efficiency of Spleen or Bone Marrow CFU in X-irradiated89Sr Marrow-ablated Mice

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Abstract
The therapeutic efficiency (TE: number of CFU [colony forming units]) required to reduce the mortality from 100-50%) of spleen or marrow (BM) stem cells (CFU) grafted into lethally irradiated mice (807 rad) previously treated with 89Sr or splenectomized was compared. During the reconstitution of the hemopoietic organs the spleen provided less than 10% of the functional cells necessary for survival. The BM-derived CFU growing in 89Sr marrow-ablated mice remained twice as efficient as the spleen-derived ones and spleen-derived CFU transplanted into splenectomized mice were half as efficient as BM-derived ones. Hemopoietic stem cells grafted into a foreign microenvironment apparently retain their original kinetics of growth and differentiation during 7-10 days after their transplantation.