Urinary Excretion of Cortisol in Acromegaly

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Abstract
Free urinary cortisol excretion was measured in 19 patients with acromegaly and 19 matched controls with other pituitary disorders who were comparable with regard to age, sex and adrenocortical response to ACTH. Cortisol Excretion was significantly higher (P < 0.01) in the acromegalics (mean, 161 .mu.g/24 h or 444 nmol/24 h) compared to the controls (mean, 82 .mu.g/24 h or 226 nmol/24 h) and normal subjects (mean, 85 .mu.g/24 h or 235 nmol/24 h). Seven of the acromegalics had excretion of urinary cortisol exceeding the upper normal limit. The most probable cause is an increased glomerular filtration of cortisol.

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