Gluconeogenic-glycolytic capacities and metabolic zonation in liver of rats with streptozotocin, non-ketotic as compared to alloxan, ketotic diabetes

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Abstract
The results indicate that both in the ketotic and nonketotic diabetic state the gluconeogenic capacity of the liver was increased mainly in the periportal zone and the glycolytic capacity was decreased mainly in the perivenous area. In both types of diabetes the glucostat function of the liver with its typical reciprocal zonal distribution of glucogenic and glycolytic enzymes was not lost, but only impaired owing to shifts of the enzyme levels in the periportal and perivenous zone. This quantitative rather than qualitative alteration would be in accord with the requirement for the liver persisting in both non-ketotic and ketotic diabetes to handle excess nutritional glucose at least in part.

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