Evidence for Multiple Muscarinic Receptor Subtypes in Human Brain
- 1 August 1984
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 43 (2) , 299-302
- https://doi.org/10.1111/j.1471-4159.1984.tb00900.x
Abstract
Pirenzepine, a compound with selective anti-muscarinic activity, was used to distinguish muscarinic acetylcholine receptor subtypes in normal human brain. Hill coefficients and IC50 values derived from the inhibition of specific [3H]l-quinuclidinyl benzilate receptor binding suggest the presence of two muscarinic binding sites, differing both in affinity for pirenzepine and in tissue distribution.Keywords
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