Hyperglucagonaemia and necrolytic migratory erythema in cirrhosis—possible pseudoglucagonoma syndrome*

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Abstract
Necrolytic migratory erythema is the distinctive cutaneous eruption seen with glucagon-producing tumors of the pancreas. Recognition of this eruption is important because it may lead to the early diagnosis of a glucagonoma. A patient who had necrolytic migratory erythema, hyperglucagonemia and cirrhosis of the liver with no evidence of pancreatic tumor while alive or at autopsy was seen. Serum glucagon levels during the period of observation and during an oral glucose tolerance test suggested that the hyperglucagonemia was not due to an occult glucagon-producing tumor but may have been the result of advanced hepatic cirrhosis.