Changes in Renal Concentrating Ability Associated with Major Surgical Procedures

Abstract
THE occurrence of acute renal failure after major surgery has centered attention on the effects of an operative procedure on renal function. Although data are available concerning the effects of anesthesia, operation and the postoperative state on urine formation, renal hemodynamics, water diuresis and electrolyte excretion,1 2 3 4 5 6 7 8 there is little information about the effect of major surgical procedures on renal concentrating ability. It has been suggested that measurement of concentrating ability is useful in differentiating postoperative oliguria due to dehydration from oliguria due to acute tubular necrosis.9 , 10 Concentrating ability is known to decrease transiently in normal subjects during hypotension11 or heavy . . .