Evidence for substantial formation of r-7, t-8-dihydroxy-c-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene-deoxyguanosine in human lymphocytes treated in vitro with benzo[a]pyrene

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Abstract
The possibility that the amounts of r-7, t-8-dihydroxy-t-9, 10-oxy-7, 8, 9, 10-tetrahydrobenzo(a) pyrene-deoxyguanosine(anti-BaP diol epoxide-dGuo) and r-7, t-8-dihydroxy-c-9, 10-oxy-7, 8, 9, 10-tetrahydrobenzo(a)pyrene-deoxyguanosine (syn-BaP diol epoxide-dGuo) may vary in human lymphocyte cultures from different donors was investigated by comparing DNA adducts formed after treatment with (G-3H)benzo(a)-pyrene (4 μM) for 24h. In most cases, >50% of the DNA adducts were derived from r-7, t-8-dihydroxy-c-9, 10-oxy-7, 8, 9, 10-tetrahydrobenzo(a)pyrene (syn-BaP diol epoxide).

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