A Mode of Action for Thyroid Inhibition by Reserpine.

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Abstract
Summary Reserpine had no significant effect upon thyroidal-I131 release rate resulting from injections of thyrotropin (TSH) into young mature female rats whose endogenous secretion of TSH was effectively blocked with thyroxine. In another experiment, reserpine prevented thyroid enlargement which normally results from administration of the goitrogen tapazole. Injections of tapazole and/or reserpine did not significantly affect pituitary or adrenal weight. It appears reserpine inhibits thyroid function in the rat through suppression of TSH secretion.