The metabolism of35S-D-penicillamine in man
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 18 (2) , 235-244
- https://doi.org/10.3109/00498258809041659
Abstract
1. The excretion and metabolism of 35S-D-penicillamine (200 mg orally) was studied in four healthy male volunteers. 2. The major route of excretion was the urine with 82% of the administered dose being voided over three days (73% during the first 24 h); the remainder was excreted in the faeces. 3. Metabolism occurred via the pathways of S-methylation, N-acetylation and disulphide formation. Extensive degradation of the molecule was observed with the production of large amounts of inorganic sulphate.This publication has 37 references indexed in Scilit:
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