Chromosome breakage and rejoining of sister chromatids in Bloom's syndrome
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Chromosoma
- Vol. 73 (3) , 275-286
- https://doi.org/10.1007/bf00288692
Abstract
The occurrence of chromosome breaks and reunion of sister chromatids in lymphocytes of two patients with Bloom's syndrome has been compared with those found in X-rayed and control cells. The distribution of breaks in BS is non-random both between and within chromosomes, the centric regions of certain chromosomes being preferentially involved. The following working hypotheses are put forward: When chromosome breaks in human lymphocytes occur in G0— G1, practically no sister chromatid reunion (SCR) takes place, whereas ends created by an S—G2 break show a considerable tendency to SCR. We propose further that chromosome aberrations in BS mainly result from breaks in S—G2, including possible U-type rejoining of sister chromatid exchanges. Fragments extra to an intact chromosome complement result from a chromatid break or an asymmetrical chromatid translocation in a previous mitosis.This publication has 14 references indexed in Scilit:
- The problem of partial endoreduplicationHuman Genetics, 1978
- The relationship between sister chromatid exchanges and chromosome aberrations in Bloom’s syndromeCytogenetic and Genome Research, 1977
- Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndromeChromosoma, 1976
- Cytological demonstration of mitotic crossing-over in manCytogenetic and Genome Research, 1976
- Cytological detection of mutagen–carcinogen exposure by sister chromatid exchangeNature, 1975
- A Manyfold Increase in Sister Chromatid Exchanges in Bloom's Syndrome LymphocytesProceedings of the National Academy of Sciences, 1974
- The internal order of the interphase nucleusPublished by Springer Nature ,1974
- Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorderChromosoma, 1974
- Cytological Evidence for Crossing-Over in vitro in Human Lymphoid CellsScience, 1964
- The Behavior in Successive Nuclear Divisions of a Chromosome Broken at MeiosisProceedings of the National Academy of Sciences, 1939