Pharmacokinetics of dibekacin in young adult and geriatric patients

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Abstract
The pharmacokinetics of dibekacin were studied in five young patients (24 to 32 years) and eight geriatric patients (69 to 86 years). All patients received a single bolus i.v. injection of 1.5 mg/kg of the antibiotic. In both kinds of patient the antibiotic followed a two-compartment open kinetic model. In the young patients, the serum half-life had an average value of 1.69 h and the apparent distribution volume was 0.21 l/kg. In geriatric patients, a decrease was observed in the elimination constant and an increase in the apparent distribution volume. The modifications observed do not necessarily justify a correction in the dosage regimen though adequate monitoring of the serum levels of the antibiotic is recommended.

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