Synthesis of Dimethoxyfuranonaftoquinones

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Abstract
Recently some furanonaphthoquinones were isolated from Tabebuia species2,3,4. The structures la, lb2, and li4 were assigned to three of these compounds (those of la and lb being later confirmed by synthesis3,5,6). However, for the three other isolated compounds the spectroscopic data did not permit a decision to be made between the 2,3,4 - - - 4 isomeric pairs of structure lc and Id, le and lf 3, and lg and lh 4. Compounds la, lb, and le (or If), were tested in the KB cell culture assay and shown to be more active cytotoxic agents than lapachol2,3, the probable biogenetic precursor of all of them.
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