Rhinocerebral Phycomycosis in Association with Diabetic Ketoacidosis
- 1 April 1967
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 66 (4) , 735-742
- https://doi.org/10.7326/0003-4819-66-4-735
Abstract
The relationship of ketoacidosis to invasiveness by this otherwise innocuous saprophyte is delineated. A summary of the clinical and experimental experience with amphotericin B in phycomycosis has been compiled, and supports the efficacy of this mode of therapy. A cumulative dose of at least 3 g of amphotericin B is recommended for treatment of rhinocerebral phycomycosis when it occurs in the decompensated diabetic. If renal toxicity becomes evident, therapy on alternate days may maintain the therapeutic effect of the drug while diminishing renal damage.Keywords
This publication has 4 references indexed in Scilit:
- Nephrotoxicity of Amphotericin BAnnals of Internal Medicine, 1964
- PHAGOCYTIC ACTIVITY OF POLYMORPHONUCLEAR LEUKOCYTES OBTAINED FROM PATIENTS WITH DIABETES MELLITUS1964
- Amphotericin B Nephrotoxicity with Irreversible Renal FailureAnnals of Internal Medicine, 1963
- MucormykosenPathobiology, 1961