Mitochondrial Water in Myocardial Ischemia: Investigation with Nuclear Magnetic Resonance
- 13 June 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4449) , 1267-1269
- https://doi.org/10.1126/science.6246584
Abstract
Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular hydration may be one of the first mechanisms to alter function in the mitochondria, which are vital to the energy-transducing process in heart muscle.Keywords
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