Effect of Sorbitol, Fructose, Succinate, Aspartate, Glutamate and Fat on Growth and Survival Time of Biotin-deficient Rats

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Abstract
In a series of experiments (randomized complete block design) using weanling male rats, the effect of sorbitol, fructose, sodium succinate, aspartate and glutamate at a level of 5 or 10% (at the expense of glucose in the basal diet containing 20% spray-dried egg white) on growth and survival time of biotin-deficient rats was studied. The test substance was included at the beginning of the experiment or after 4 weeks on the basal diet. Under these conditions no significant effect on growth or survival time of biotin-deficient rats was observed. Addition of 10 or 20% fat to the basal diet containing 4% corn oil resulted in a significant increase in growth and survival time of deficient animals.