PHOSPHATIDES IN THE MORPHOLOGY OF INJURED TISSUE

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Abstract
In vitro microscopic examination of human placental tissue fragments showed development of elongate pleomorphic myelin figures within fluid filled spaces and at the tissue periphery, deformation and emigration of lipid droplets into the surrounding fluid, and formation of intravascular and peripheral translucent globular bodies which continued to form in the presence of enzyme inhibitors and were disrupted by phosphatidease “A”‐containing solutions. It is concluded that the translucent globular bodies are vesicular myelin figures caused by minimal phosphatide liberation, that lipid droplet deformation and emigration result from physico‐chemical surface changes in the lipid droplets and that the process of myelin figure formation is significant in both the morphological changes of injured tissues and tissue autolysis.