EFFECTS OF CHLORPROMAZINE ON LIPOLYSIS IN BROWN AND WHITE ADIPOSE TISSUES OF COLD-EXPOSED RATS

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Abstract
Effects of chlorpromazine (CPZ) on lipolysis in brown (intercapular: IBAT) and white (epididymal: EWAT) adipose tissues in cold-exposed rats were studied in vitro. Adult male Wistar-Imamichi rats were exposed to 4.degree. C for 1 (acute cold-exposed) or 30 (cold-acclimated) days. The spontaneous free fatty acid (FFA) release from IBAT of control rats was 3-fold higher than EWAT. FFA release from the EWAT of acute cold-exposed rats was significantly higher than that of control rats. After cold acclimation, FFA release from IBAT increased up to 3 times that of the control level. CPZ (10-4, 10-3 M) suppressed the elevated lipolytic activity in IBAT of cold-acclimated rats. CPZ had no effect on FFA release from EWAT or IBAT in all other groups. A single i.v. administration of 10 mg/kg 6-hydroxy-dopamine (6-OHDA) produced a marked decrease in the concentration of noradrenaline [norepinephrine, NA] and dopamine in IBAT and EWAT of cold-acclimated rats. FFA release from IBAT in 6-OHDA treated, cold-acclimated rats decreased to 50% of untreated, cold-acclimated rats. A further decrease in lipolytic activity in the IBAT of 6-OHDA treated, cold-acclimated rats was produced following CPZ treatment. CPZ depressed the lipolysis stimulated by the added NA (3 .times. 10-5 M). Apparently the effect of CPZ on the lipolysis in the IBAT from cold-acclimated rats is mediated by a modification of sympathetic activity.

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