Role of brown adipose tissue in the thermal response to chlorpromazine in rats during cold exposure

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Abstract
Significance of the interscapular brown adipose tissue(IBAT) in the thermal response to chlorpromazine(CPZ) during acute and chronic cold exposure was studied in rats. Adult male Wistar-Imamichi rats were exposed to 4.degree. C for 1 (cold-exposed) or 30 days (cold-acclimated). I.p. injection of 10 mg/kg CPZ caused a more marked and lasted hypothermia in acute cold-exposed rats as compared with that seen in control or in cold-acclimated rats. Hypothermia induced by CPZ was unaffected by removal of IBAT either in control or acute cold-exposed rats. In cold-acclimated rats, the removal of IBAT potentiated the hypthermia by CPZ. The relative weight of IBAT in cold-acclimated rats was about 3 times heavier than that in control and acute cold-exposed rats. CPZ had no effect on the relative weight of IBAT in all groups examined. Total lipids in IBAT showed no significant changes following CPZ administration in rats of all groups. In acute cold-exposed rats, serum FFA [free fatty acid] level progressively decreased after CPZ injection. The noradrenaline [norepinephrine] concentration in IBAT increased after chronic cold exposure and CPZ suppressed this elevation. The thermogenesis-related sympathetic activity in the IBAT plays a mediatory role in thermal response to CPZ during cold acclimation.

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