Role of Adrenaline and Nor-Adrenaline on Response of Cold-Acclimatized Animals to Chlorpromazine

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Abstract
The antagonistic effect of a acclimatization on chlorpromazine hypothermia is associated with increased sensitization of tissues to epinephrine and nor-epinephrine. Although normally these substances have no effect on chlorpromazine hypothermia, they potentiate the antagonism of acclimatization towards the drug. Furthermore, dibenamine completely abolishes this antagonism. On the other hand, results are presented suggesting that acclimatization to cold may also be associated with a desensitization to histamine.

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