Effect of Injection of Rabbit Leucocytes into Neonatal Rabbits on Subsequent Lymph Node Cell Transfer.

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Abstract
Newborn rabbits were injected with leucocytes obtained from adult rabbits which were prospective donors of lymph node cells. When antigen-incubated lymph node cells from these donors were transferred to the young rabbits 1-2 1/2 months later, agglutinins failed to appear, or did so in low titer. This suppression of the transferred lymph node cells indicated that the tissues of the newborn rabbits had failed to develop tolerance to leucocyte antigens of the donor animals, but had developed an immunologic reaction against the antigens of the leucocytes of the donor animals. The transfer of lymph node cells incubated in vitro with Shigella-trypsin filtrate to uninjected newborn rabbits (1-11 days of age) resulted in the appearance of anti-Shigella agglutinins. Although the amount of agglutinin produced per transferred cell was definitely less in the neonatal recipient, it was clear that the tissues of the neonatal rabbit were able to support the function of the transferred cells.

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