Aldosterone and cardiovascular remodelling: focus on myocardial failure
- 1 March 2004
- journal article
- review article
- Published by SAGE Publications in Journal of the Renin-Angiotensin-Aldosterone System
- Vol. 5 (1) , 3-13
- https://doi.org/10.3317/jraas.2004.005
Abstract
Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.Keywords
This publication has 136 references indexed in Scilit:
- Endothelin Antagonism on Aldosterone-Induced Oxidative Stress and Vascular RemodelingHypertension, 2003
- Increased Carotid Wall Elastic Modulus and Fibronectin in Aldosterone-Salt–Treated RatsCirculation, 2002
- The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart FailureNew England Journal of Medicine, 1999
- Superoxide Anion Production Is Increased in a Model of Genetic HypertensionHypertension, 1999
- Angiotensin AT 1 Receptor Subtype as a Cardiac Target of AldosteroneHypertension, 1999
- Oxidative Stress in the Dahl Hypertensive RatHypertension, 1997
- Vascular Aldosterone in Genetically Hypertensive RatsHypertension, 1997
- Potentiation of angiotensin II action by corticosteroids in vascular tissueCardiovascular Research, 1996
- Effects of Enalapril on Mortality in Severe Congestive Heart FailureNew England Journal of Medicine, 1987
- Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscleLife Sciences, 1982